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Mpox Vaccine Study To Begin In DRC Amid Outbreak

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A new study is set to begin in the Democratic Republic of Congo (DRC) to assess the efficacy of the LC16m8 Mpox vaccine in African populations.

The launch comes as the country battles a major outbreak of the virus, which remains a continental public health emergency.

Health experts say the ongoing vaccination campaign in DRC offers a rare chance to gather real-world evidence about the vaccine’s performance. The study will look at how effective the vaccine is at preventing Mpox, including among children.

The Coalition for Epidemic Preparedness Innovations (CEPI) is funding the project with up to 10.4 million US dollars, a statement issued on September 11, 2025, said. The International Vaccine Institute (IVI) will serve as the study sponsor, while the Institut National pour la Recherche Biomédicale (INRB) in the DRC will co-sponsor and also lead the research and the Japan Institute for Health Security (JIHS) will act as a co-investigator.

The study is supported by the DRC Ministry of Health and the Institut National de Santé Publique (INSP) and is expected to begin this Autumn once regulatory and ethics approvals are completed.

Researchers will monitor vaccinated people in hotspot health zones in Équateur Province. They will track how many still get infected and also collect safety data from a subset of participants.

The findings are expected to guide vaccination strategies in the DRC and other Mpox-endemic regions. They could also help decide which age groups should be prioritized for vaccination.

Japan has donated three million doses of LC16m8 to DRC to protect at-risk populations. The vaccine, developed by KM Biologics, has been licensed in Japan for decades as a smallpox vaccine. It is safe and effective, including in people with well-controlled HIV.

The DRC Health Minister, Samuel Roger Kamba, said the country will be the first in Africa to collect real-world field data on the vaccine.

“The epidemiological data on Mpox have enabled us to support the response with vaccination of the populations. With this collaborative research, the DRC will be the first African country to collect essential field data on the use of the LC16m8 vaccine against Mpox.”

Dr. Manabu Sumi of Japan’s Health Ministry said LC16m8 is the only Mpox vaccine currently approved for children and could protect people of all ages.

“Building on the findings of this trial and Japan’s accumulated experience, the Ministry looks forward to working with international partners to further enhance LC16m8’s contribution to global preparedness and response efforts against Mpox.”

Africa CDC Director-General, Dr. Jean Kaseya, described the study as “a vital step in protecting Africa’s most vulnerable, especially children.”

“By turning science into action, we are building the evidence needed to guide vaccination and strengthen health security across the continent.”

Other partners, including INRB and JIHS, stressed that the project will also strengthen Africa’s ability to respond to future health emergencies.

Director-General of INRB and Principal Investigator, Prof. Jean-Jacques Muyembe, said scientific collaboration is key.

“The results generated by this study will serve as an effective guide for future Mpox outbreaks,” he said.

Dr. Norio Ohmagari of JIHS said the trial will provide rigorous real-world evidence, while Dr. Mugen Ujiie of the same institute highlighted Japan’s commitment to protecting communities from Mpox.

“The findings will help inform equitable and effective vaccination strategies across affected regions,” Dr Ujiie said.

The International Vaccine Institute’s Deputy Director General, Dr. Florian Marks, added that the study will also help build local research capacity.

“In close partnership with INRB, JIHS, CEPI, and local health teams, we are also working to strengthen local research capacity so that communities are better equipped to respond to future health emergencies,” he said.

General Director of INSP, Dr. Dieudonné Mwamba, said vaccination remains a key pillar in responding to epidemics.

Mpox, formerly known as monkeypox, causes fever, headache, muscle aches, swollen lymph nodes and skin rashes with blisters. The disease can be deadly in severe cases.

WHO and Africa CDC declared the ongoing outbreak a global and continental emergency in August 2024. As of September 2025, Mpox remains a continental health emergency in Africa.

myjoyonline.com

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Africa

Toddlers Among Over 50 School Children Abducted In Nigeria

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Gunmen have kidnapped more than 50 children from three schools in the same town in north-eastern Nigeria, teachers and parents have told the BBC.

Most of those missing are aged between two and five years old.

Eyewitnesses who saw the attacks on Friday morning in Mussa, Borno state, say the suspects used the children as human shields while fleeing on motorbikes, preventing security forces from opening fire.

No group has claimed responsibility for the attacks. Government officials have not responded to the BBC’s requests for comment, but a press statement issued on Saturday by Senator Ali Ndume of Borno South said at least 42 children had been abducted from two schools.

The kidnappings took place at the town’s Government Day Secondary School, Mussa Central Primary School, and State Universal Basis Education Board (SUBEB) Secondary School.

Some reports suggest the attacks bore the hallmark of Boko Haram – the Islamist group vying for control over the region against its rival faction, Islamic State West Africa Province (Iswap).

Nigeria is currently grappling with a spate of mass abductions by a range of culprits.

Locals in Borno state have endured decades of insecurity. These latest attacks have prompted some resident of Mussa to flee the area.

Yet traumatised parents have told the BBC they feel they have no choice but to wait in anguish for news about their children.

One man, who did not want to be named for fear of reprisal, said his wife was inconsolable after their six-year-old daughter was snatched away by the gunmen.

Abdu Dunama, headmaster of Mussa Central Primary School, described hearing gunfire before armed men stormed the school and rounded up children.

He said 34 children – mostly nursery pupils aged five and under – were seized by the attackers from their classrooms.

The suspected militants arrived at the schools on motorcycles soon after troops on patrol left the town, according to residents.

“[It was] immediately after they left, it was not up to 30 minutes after,” said Bukar Buba, whose daughter was taken.

Witnesses said the gunmen fired sporadically, forcing residents to run for cover. Many parents watched helplessly from a nearby hill as their children were loaded onto motorcycles and taken away.

Some older students managed to flee into nearby bushes during the chaos, according to residents.

The largely farming community – already struggling economically – is now appealing urgently to the government to help secure the safe return of the children.

Dunama, who is in touch with security forces, says troops are currently on the ground and continuing efforts to track the abductors.

myjoyonline.com

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International

Three Dead In Suspected Virus Outbreak On Atlantic Cruise Ship

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Three people have died and a UK national is seriously ill in hospital after a suspected hantavirus outbreak on a small cruise ship in the Atlantic Ocean.

The operator of the MV Hondius ship, tour company Oceanwide Expeditions, said a Dutch husband and wife, as well as a German national, have died but the cause has not yet been established.

However, the Dutch company said hantavirus has been confirmed in the case of the 69-year-old UK national who is in intensive care in Johannesburg, South Africa.

Hantavirus is usually passed to humans from rodents via their faeces, saliva or urine. It can cause severe respiratory illness. Rarely, it can be transmitted between people.

Oceanwide Expeditions said there were two crew members on board “with acute respiratory symptoms, one mild and one severe”.

They both require urgent medical care and are of British and Dutch nationality, it said, before adding that no other persons with symptoms had been identified at this time.

The World Health Organization (WHO) said it was “acting with urgency” to support the MV Hondius and thanked South African authorities for taking care of the British patient.

WHO’s regional director for Europe, Dr Hans Henri P Kluge, said: “I am in close contact with our teams to ensure a co-ordinated, science-based response.

“Hantavirus infections are uncommon and usually linked to exposure to infected rodents.

“While severe in some cases, it is not easily transmitted between people. The risk to the wider public remains low. There is no need for panic or travel restrictions.”

The MV Hondius vessel is currently off the coast of Cape Verde and has 149 people onboard.

Negotiations are in progress with local authorities following what Oceanwide Expeditions described as “a serious medical situation”.

Outlining a timeline, the company said a passenger became unwell while onboard and died on 11 April.

His cause of death could not be determined, and his body was taken off the ship after it docked at St Helena on 24 April.

The wife also disembarked on St Helena and the firm said it was told she became unwell during the return journey and later died.

“At this time, it has not been confirmed that these two deaths are connected to the current medical situation on board,” Oceanwide Expeditions added.

On 27 April, the firm said, another passenger – the British national – became seriously ill and was “medically evacuated” to South Africa.

The 69-year-old remains in a critical but stable condition in Johannesburg after it was confirmed a variant of hantavirus had been identified.

A map showing the route of the cruise ship from Ushuaia, Argentina, across the South Atlantic Ocean to Cape Verde.

The firm added that on Saturday, a third passenger onboard MV Hondius died.

Although the cause of death has not been established, Oceanwide Expeditions confirmed the passenger was German.

“In addition, there are currently two crew members on board with acute respiratory symptoms, one mild and one severe,” the firm said.

“Both require urgent medical care. These crew members are of British and Dutch nationality,” it said.

Oceanwide Expeditions said the cause of the deaths were being investigated.

“The disembarkation of passengers, medical evacuation and medical screening require permission from, and co-ordination with, the local health authorities.

“Local health authorities have visited the vessel and assessed the situation. The medical transfer of the two ill persons on board has not yet taken place,” the company said.

According to the South African government, MV Hondius departed from Ushuaia in southern Argentina about three weeks ago, before it completed its journey to Cape Verde, where it is anchored outside the capital, Praia.

It is described as a 107.6m (353ft) polar cruise ship, with space for 170 passengers in 80 cabins, along with 57 crew members, 13 guides and one doctor.

One passenger onboard the MV Hondius, who asked to remain anonymous, told the BBC: “The latest word is that a plane is on its way and once it gets here three people will be evacuated from the ship and flown straight to Europe.

“Then the rest of us will almost certainly sail to the Canary Islands.

“The Cape Verde authorities clearly want nothing to do with us. This is what we’re hearing from the captain and staff. From what I can see the mood (on the ship) is pretty good.

“Only one person has been tested (the one now in South Africa) and he tested positive for hantavirus. So, we don’t actually know yet if the other cases are that or something unrelated.

“If they are all hantavirus then the transmission is a bit mysterious. We’ve been informed that there are no rodents on board, and person-to-person transmission is difficult/rare.

“Hopefully the other patients on board will be tested soon and then we’ll know better what’s going on.”

President of the Cape Verdean Public Health Institute, Maria Da Luz, said passengers would not be disembarking in Cape Verde in order to protect the local population, Cape Verde’s media outlet A Nacao reports.

MV Hondius during a trip from Argentina to Antarctica via South Georgia
MV Hondius during a trip from Argentina to Antarctica via South Georgia in November 2021

Microbiologist Siouxsie Wiles told the BBC the time between exposure to hantavirus and symptom onset could be as long as eight weeks.

“With this incubation period are we going to see more people coming down with the disease in the next days and weeks?”

Oceanwide Expeditions said it is liaising with local authorities and is also preparing for a “possible medical repatriation”.

The option of sailing on to Las Palmas or Tenerife in the Spanish Canary Islands is “being considered”.

Strict precautionary measures are in process on board, including isolation measures, hygiene protocols and medical monitoring,” the Oceanwide Expeditions added.

“All passengers have been informed and are being supported. Oceanwide Expeditions is in close contact with those directly involved and their families, and is providing support where possible.”

The UK Foreign Office told the BBC it was monitoring reports, and ready to support British nationals.

Hantavirus was in the headlines last year after the wife of Oscar-winning actor Gene Hackman died from a respiratory illness linked to hantavirus in March 2025.

bbc.com

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International

SA Xenophobic Attacks: Close Shops, Avoid Protest Areas – Ghana Mission Warns

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The Ghana High Commission in Pretoria has urged members of the Ghanaian community in South Africa to exercise heightened caution ahead of planned demonstrations over immigration issues.

This is on the back of reports and viral videos of xenophobic incidents targeting foreign nationals, including Ghanaians, in some parts of the country.

In a notice issued on Tuesday, April 28, the mission advised Ghanaians, particularly those in Pretoria, to prioritise their personal safety as a group identified as the March Organisation prepares to march to the Presidency to present its grievances.

“I urge everyone to continue exercising heightened vigilance and to place the highest priority on personal safety during this period,” the statement said on behalf of the High Commissioner, Benjamin Anani Quashie.

The High Commission specifically called on Ghanaian shop owners to shut their businesses for the day and avoid areas where protests are expected.

“Shop owners are strongly encouraged to close their businesses for the day and avoid areas where protests or demonstrations are taking place,” it said.

It also cautioned nationals against taking part in any public gatherings that could escalate into confrontations.

“Please refrain from participating in public gatherings that could escalate into confrontation,” the statement added.

Ghanaians were further advised to maintain a low profile and act with discretion both in public and online, including avoiding the sharing of content that could be seen as provocative or inflammatory.

The High Commission said it would provide further updates as the situation develops.

citinewsroom.com

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